01of 04Oprah Winfrey & Gayle KingOprah Winfrey and Gayle King.Joe PuglieseI always get, ‘This is my Oprah,’ " King tells PEOPLE of encounters from fans who see themselves in the pair, friends for 46 years. “It’s one of the biggest compliments.” Adds Winfrey: “And I always get, ‘This is my Gayle.’ I understand what that means: long-term, standing in the gap, no matter what.“02of 04Sydney Sweeney & Maude ApatowSydney Sweeney (left) and Maude Apatow.Michael AvedonThe young actresses have been inseparable since meeting on the set of their HBO hit,Euphoria,four years ago. “Everyone knows that if I’m not in my trailer, I’m in Maude’s,” Sweeney tells PEOPLE. “She’s the sister I always wish I had.” Adds Apatow, “It’s nice knowing we always have each other.“03of 04Octavia Spencer & Allison JanneyOctavia Spencer and Allison Janney.Michael Avedon"She didn’t like me,” Janney tells PEOPLE of her early days with now-bestie of 20-plus years, Spencer, after they once pined for the same guy. “Our friendship has lasted so much longer than that guy,” says Spencer. “It’s true love!“04of 04Sarah Paulson & Amanda PeetMichael AvedonPaulson says her relationship with her friend of 23 years is “incredibly grounding … but also wildly chaotic in the most fun way possible.” Adds Peet: “I don’t like when she leaves me.”

01of 04Oprah Winfrey & Gayle KingOprah Winfrey and Gayle King.Joe PuglieseI always get, ‘This is my Oprah,’ " King tells PEOPLE of encounters from fans who see themselves in the pair, friends for 46 years. “It’s one of the biggest compliments.” Adds Winfrey: “And I always get, ‘This is my Gayle.’ I understand what that means: long-term, standing in the gap, no matter what.”

01of 04

Oprah Winfrey & Gayle King

Oprah Winfrey and Gayle King.Joe Pugliese

Oprah Winfrey and Gayle King photographed in Santa Barbara on April 2nd

I always get, ‘This is my Oprah,’ " King tells PEOPLE of encounters from fans who see themselves in the pair, friends for 46 years. “It’s one of the biggest compliments.” Adds Winfrey: “And I always get, ‘This is my Gayle.’ I understand what that means: long-term, standing in the gap, no matter what.”

02of 04Sydney Sweeney & Maude ApatowSydney Sweeney (left) and Maude Apatow.Michael AvedonThe young actresses have been inseparable since meeting on the set of their HBO hit,Euphoria,four years ago. “Everyone knows that if I’m not in my trailer, I’m in Maude’s,” Sweeney tells PEOPLE. “She’s the sister I always wish I had.” Adds Apatow, “It’s nice knowing we always have each other.”

02of 04

Sydney Sweeney & Maude Apatow

Sydney Sweeney (left) and Maude Apatow.Michael Avedon

Sydney Sweeney and Maude Apatow photographed exclusively for People Magazine by Michael Avedon, on April 14th 2022 in LA.

The young actresses have been inseparable since meeting on the set of their HBO hit,Euphoria,four years ago. “Everyone knows that if I’m not in my trailer, I’m in Maude’s,” Sweeney tells PEOPLE. “She’s the sister I always wish I had.” Adds Apatow, “It’s nice knowing we always have each other.”

03of 04Octavia Spencer & Allison JanneyOctavia Spencer and Allison Janney.Michael Avedon"She didn’t like me,” Janney tells PEOPLE of her early days with now-bestie of 20-plus years, Spencer, after they once pined for the same guy. “Our friendship has lasted so much longer than that guy,” says Spencer. “It’s true love!”

03of 04

Octavia Spencer & Allison Janney

Octavia Spencer and Allison Janney.Michael Avedon

Allison Janney and Octavia Spencer photographed exclusively for People Magazine by Michael Avedon, on April 16th 2022 in LA.

“She didn’t like me,” Janney tells PEOPLE of her early days with now-bestie of 20-plus years, Spencer, after they once pined for the same guy. “Our friendship has lasted so much longer than that guy,” says Spencer. “It’s true love!”

04of 04Sarah Paulson & Amanda PeetMichael AvedonPaulson says her relationship with her friend of 23 years is “incredibly grounding … but also wildly chaotic in the most fun way possible.” Adds Peet: “I don’t like when she leaves me.”

04of 04

Sarah Paulson & Amanda Peet

Michael Avedon

Amanda Peet and Sarah Paulson photographed exclusively for People Magazine by Michael Avedon, on April 15th 2022 in LA.

Paulson says her relationship with her friend of 23 years is “incredibly grounding … but also wildly chaotic in the most fun way possible.” Adds Peet: “I don’t like when she leaves me.”

source: people.com